Galanthamine hydrobromide CAS NO.1953-04-4

ProductName:GalanthamineHydrobromide OriginalPlant:ShorttubeLycoris Appearance:Whitetowhitishcrystalpowder Specification:99% …

Product Name:Galanthamine Hydrobromide
Original Plant:Shorttube Lycoris
Appearance:White to whitish crystal powder
Specification:99%
Synonym(s):Reminyl, Nivalin
Chemical Name:(4aS,6R,8aS)-6-Hydroxy-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-benzofuro[3a,3,2-e,f][2]benzazepine hydrobromide
Test  Method:HPLC
Molecular Formula:C17H21NO3.HBr;C17H22BrNO3
Molecular Weight:368.27
CAS No.:1953-04-4

Pharmacology Action:
Galanthamine extract is specific, competitive and reversible acetylcholinesterase inhibitor. It is also an allosteric modulator at nicotinic cholinergic receptor sites potentiating cholinergic nicotinic neurotransmission. Both the acetylcholine and nicotine receptors have been suggested as areas related to cognitive impairment. Initially, Galanthamine extract was used in anesthesiology to antagonize the effects of non-depolarizing muscle relaxants, and since then it was rapidly introduced in other areas of medicine, i.e. neurology, ophthalmology, gastroenterology, intensive care and resuscitation, cardiology, physiotherapy.Several trials already showed that Galantamine 16 and 24 mg/day significantly benefits the cognitive, functional, and behavioral symptoms of AD as compared with placebo and proved also to be very effective in symptomatic treatment of senile dementia of Alzheimer's type.